Abbreviationslist:AVSD (atrioventricular septal defect), CHD (congenital heart disease), DILV (double inlet left ventricle), f-SV (functionally single ventricle), FUH (functionally univentricular heart), HLHS (hypoplastic left heart syndrome), IQR (interquartile range (second and third quantiles)), NCHDA (National Congenital Heart Diseases Audit), ONS (Office of National Statistics)
Publication stageIn Press Journal Pre-Proof
Conflict of interest
This study was funded by the British Heart Foundation (Project Grant no. PG/17/88/33401). Victor Tsang and Katherine Brown received support from the NIHR Biomedical Research Centre at Great Ormond Street Hospital.
IRB/REC approval: 15 Oct 2018 from Stanmore REC 18/LO/1688, the need for patient consent was waived.
Central Picture: Legend: Functionally single ventricle (f-SV) centre-volume by complexity and five-year survival. f-SV: functionally single ventricle; High-risk subtypes are AVSD=(unbalanced) atrioventricular septal defect and HLHS=hypoplastic left heart syndrome.
Central Message: In the centralised service provided for children with f-SV hearts in England, we found no evidence for a relationship between centre-volume and long-term survival after adjusting for case mix.
Perspective: The survival rate for patients with f-SV disease at one year and five years, was 76.8% (95%CI 75.3%,78.2%) and 72.1% (95%CI 70.6%,73.7%), respectively. After adjusting for risk factors, there was no evidence that centre-volume was associated with long term survival, i.e., HR 1.01 (95%CI 0.99,1.04) p=0.28. Higher volume centres tended to treat children with more complex disease (HLHS, Norwood pathway).
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