Congenital: Pediatric Lung Transplantation| Volume 165, ISSUE 4, P1519-1527.e4, April 2023

A multicentric evaluation of pediatric lung transplantation in Italy



      Pediatric lung transplantation is performed in highly experienced centers due to the peculiar population characteristics. The literature is limited and not representative of individual countries' differences. The purpose of this study was to analyze the Italian experience.


      A multicentric retrospective analysis was performed on 110 pediatric patients (<18 years old) who underwent lung transplantation from 1992 to 2019 at 9 Italian centers. Heart–lung transplantations and lung retransplantations were excluded.


      The population was composed of 44 male and 66 female patients, with a median age of 15 years. The most frequent indication was cystic fibrosis (83%). One quarter of patients were transplanted in an emergency setting. Median donors' Oto score and age were 1 and 15 years, respectively, with 43% of adult donors. In 17% of patients a graft reduction was performed. Postoperatively, the median duration of mechanical ventilation, intensive care unit, and in-hospital stay were 48 hours, 11 and 35 days, respectively. Thirty-day mortality was 6%, and 1-, 5-, and 10-year survival was 72%, 52%, and 33%, respectively. Risk factors for mortality were Oto score and recipients' body mass index.


      The outcomes of pediatric lung transplantation in Italy are comparable with current literature. Particular attention should be paid to the Oto score and recipient body mass index. Conversely, adult donors and graft reductions can be safely used to expand the donor pool.

      Graphical abstract

      Key Words

      Abbreviations and Acronyms:

      BMI (body mass index), CI (confidence interval), CLAD (chronic lung allograft dysfunction), CPB (cardiopulmonary bypass), ECMO (extracorporeal membrane oxygenation), FEV1 (forced expiratory volume in 1 second), HR (hazard ratio), ICU (intensive care unit), ISHLT (International Society of Heart and Lung Transplantation), IQR (interquartile range), MV (mechanical ventilation), OR (odds ratio), PGD (primary graft dysfunction), TLC (total lung capacity)
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