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Abbreviations and Acronyms:
ACEI (angiotensin-converting enzyme inhibitor), ARB (angiotensin receptor blocker), CABG (coronary artery bypass grafting), CAD (coronary artery disease), CV (cardiovascular), HF (heart failure), KCCQ (Kansas City Cardiomyopathy Questionnaire), LV (left ventricular), LVEF (left ventricular ejection fraction), MI (myocardial infarction), NYHA (New York Heart Association), OMT (optimal medical therapy), PCI (percutaneous coronary intervention), STICH (Surgical Treatment for Ischemic Heart Failure)Purchase one-time access:
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Footnotes
This work was supported by Grants U01HL69015, U01HL69013, and RO1HL105853 from the National Institutes of Health and National Heart, Lung, and Blood Institute. This work is solely the responsibility of the authors and does not necessarily represent the official views of the National Heart, Lung, and Blood Institute or National Institutes of Health.
There is no additional Institutional Review Board approval required for this analysis because this is a post hoc analysis based on the existing STICH database, that is, no new data are collected and consent had been obtained from every patient in the STICH trial.
Clinical Trial Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT00023595.
Working Group: Rafal Dabrowski, MD, PhD,h Ljubomir Djokovic, MD,i Mark Drazner, MD,j Haissam Haddad, MD,k Imtiaz S. Ali, MD,l Matyas Keltai, MD,m Ajay Naik, MD,n George Sopko, MD,o Krzysztof Golba, MD,p Bert Andersson, MD,q Peter Carson, MD,r and Tomasz Kukulski, MDs
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- Commentary: A stitch in time saves nine, but medical therapy makes that stitch shineThe Journal of Thoracic and Cardiovascular SurgeryVol. 164Issue 6
- PreviewIschemic cardiomyopathy (ICM) is a leading cause of morbidity and mortality across the globe, with a rapidly growing number of affected patients in the US and a poor prognosis overall.1 Median survival is not substantially greater than 5 years in patients with ICM and reduced ejection fraction (EF).2 Although primary prevention of coronary artery disease (CAD) is the sole hope of effectively lessening the societal burden of this disease, effective secondary prevention can preserve some quality and quantity of life in patients diagnosed with ICM.
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- Commentary: Just what the doctor ordered: The as-yet unrealized gains of optimal medical therapy for ischemic cardiomyopathyThe Journal of Thoracic and Cardiovascular SurgeryVol. 164Issue 6
- PreviewIn their post hoc analysis of data obtained from the Surgical Treatment for Ischemic Heart Failure (STICH) trial, Farsky and colleagues1 substantiate the benefit of optimal medical therapy (OMT) on long-term survival after surgical coronary revascularization in patients suffering from ischemic cardiomyopathy. This finding is particularly important given the surprisingly low adherence to OMT and attenuated long-term survival rates in these high-risk patients.
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