Less invasive aortic valve operations through a partial sternotomy or minithoracotomy can be performed with conventional bioprostheses.
- EIBardissi A.W.
- Shekar P.
- Couper G.S.
- Cohn L.H.
Minimally invasive aortic valve replacement in octogenarian, high-risk, transcatheter aortic valve implantation candidates.
J Thorac Cardiovasc Surg. 2011; 141: 328-335
2Totally endoscopic aortic valve replacement (TEAVR) has not previously been feasible, because the currently available designs of stented tissue valves do not allow them to fit through a trocar. The recent advent of sutureless bioprostheses, mounted on a compressible self-expanding nitinol stent, has made this possible. We report the first TEAVR procedures in 2 patients through conventional thoracoscopic trocars.
- Glauber M.
- Miceli A.
- Gilmanov D.
- Ferrarini M.
- Bevilacqua S.
- Farneti P.A.
- et al.
Right anterior minithoracotomy versus conventional aortic valve replacement: a propensity score matched study.
J Thorac Cardiovasc Surg. 2013; 145: 1222-1226
Proof-of-concept of TEAVR was first achieved in cadavers, and institutional ethics committee approval and patients' consent were obtained before the operation. The first patients treated, patients 1 and 2, were male, aged 83 and 82 years, respectively, and had aortic valve stenosis. Preoperative mean transvalvular aortic valve gradient, ejection fraction, and body surface area were 52 and 47 mm Hg, 61% and 45%, and 1.97 and 2.00 m2, respectively. Preoperative thoracic computed tomography was used to assess the degree of calcification and anatomic suitability (Figure 1, A). Suitable patients have a long (≥5 cm) ascending nonvertical aorta (with a physiologic curvature), with sufficient periaortic working space (≥2 cm) between the sternum and the aortic wall. We also used the computed tomographic scan to measure the diameter of the aortic annulus, which was compared with the transesophageal echocardiographic findings of 2 independent operators to determine the appropriate size of the bioprosthesis. For both procedures, under selective ventilation, 5 trocars (Flexipath; Ethicon, Inc, Somerville, NJ) were introduced in the right hemithorax (Figure 1) and femorofemoral cardiopulmonary bypass (CPB) was initiated. After transcutaneous aortic crossclamping (Chitwood clamp; Geister, Tuttlingen, Germany), antegrade cardioplegia (histidine-tryptophan-ketoglutarate cardioplegic solution; Kohler Chemie, Alsbach-Hahnlein, Germany) and aortotomy, valvular and annular calcifications were removed. Both patients received 3f Enable sutureless aortic bioprostheses (Medtronic, Inc, Minneapolis, Minn), 27 mm and 23 mm, respectively, each reduced to 19 mm by compression of the nitinol stent and introduced into the main trocar (20 mm). In each patient, the appropriate valve was inserted into the ascending aorta and expanded and fixed in the annulus (Figure 2). Air embolism was prevented through continuous insufflation of carbon dioxide. After closure of the aorta, reinsertion of an aortic vent, and left table tilting, we monitored deairing of residual bubbles in the ventricle under transesophageal echocardiographic control. Aortic crossclamping and CPB times were 102 and 145 minutes in the first patient and 110 and 150 minutes in the second patient, respectively. An intraoperative transesophageal echocardiogram confirmed the absence of paravalvular leakages. Hospital discharge was uneventful in both cases (both after 7 days), and no surgical revision, stroke, myocardial infarction, renal insufficiency, pacemaker implantation, or other complications were reported.
In our institution, moving toward a less invasive technique has required a stepwise approach, starting with the adoption of the ministernotomy technique as routine. We then transitioned to the right minithoracotomy approach, first under direct view, then with an endoscopic camera, and, finally, by means of a totally endoscopic technique. It is important to note that when performing a totally endoscopic procedure, a quick and safe conversion to minithoracotomy under direct view can be made if circumstances demand, which would still offer significantly reduced chest trauma.
Totally endoscopic surgery in other fields, such as atrial septal defect repair and coronary artery bypass grafting, has shown improved quality of life but with longer clamping and CPB times during the learning curve.
- Morgan J.A.
- Peacock J.C.
- Kohmoto T.
- Garrido M.J.
- Schanzer B.M.
- Kherani A.R.
- et al.
Robotic techniques improve quality of life in patients undergoing atrial septal defect repair.
Ann Thorac Surg. 2004; 77: 1328-1333
4Considering that the TEAVR cases described here were our first procedures, we believe that clamping and CPB times were acceptable and suggest that the learning curve associated with TEAVR could be shorter than that reported with totally endoscopic coronary artery bypass grafting. The potential of this approach could be further enhanced by the development of endoscopic sizers as well as dedicated instruments for decalcification.
- Bonaros N.
- Schachner T.
- Lehr E.
- Kofler M.
- Wiedemann D.
- Hong P.
- et al.
Five hundred cases of robotic totally endoscopic coronary artery bypass grafting: predictors of success and safety.
Ann Thorac Surg. 2013; 95: 803-812
Second-generation sutureless bioprostheses could also simplify implantation, although this did not require more than 45 minutes in either patient. Devices to facilitate a technically demanding aortotomy closure are also critically important. In fact, closing the aorta consumed more than 30% of the clamping time in both cases, despite the fact that we selected patients with adequate working space around the ascending aorta. Last but not least, surgical robots may offer additional benefits to the totally endoscopic approach. Previously, only a proof-of-concept in cadavers
5through a standard minithoracotomy access has been published.
- Suri R.M.
- Burkhart H.M.
- Schaff H.V.
Robot-assisted aortic valve replacement using a novel sutureless bovine pericardial prosthesis: proof of concept as an alternative to percutaneous implantation.
Innovations (Phila). 2010; 5: 419-423
These first procedures show that totally endoscopic sutureless aortic valve replacement is technically feasible. Further clinical experience and technical development are necessary to shorten operation times and to assess further the potential postoperative benefits of TEAVR.
We thank Dr Antoine Gerbay and Dr Marie Levallois for the echocardiographic support.
- Minimally invasive aortic valve replacement in octogenarian, high-risk, transcatheter aortic valve implantation candidates.J Thorac Cardiovasc Surg. 2011; 141: 328-335
- Right anterior minithoracotomy versus conventional aortic valve replacement: a propensity score matched study.J Thorac Cardiovasc Surg. 2013; 145: 1222-1226
- Robotic techniques improve quality of life in patients undergoing atrial septal defect repair.Ann Thorac Surg. 2004; 77: 1328-1333
- Five hundred cases of robotic totally endoscopic coronary artery bypass grafting: predictors of success and safety.Ann Thorac Surg. 2013; 95: 803-812
- Robot-assisted aortic valve replacement using a novel sutureless bovine pericardial prosthesis: proof of concept as an alternative to percutaneous implantation.Innovations (Phila). 2010; 5: 419-423
Published online: December 02, 2013
Accepted: October 6, 2013
Received in revised form: September 29, 2013
Received: August 12, 2013
Disclosures: Marco Vola reports consulting and lecture fees from Medtronic. Jean-François Fuzellier reports lecture fees from Medtronic. All other authors have nothing to disclose with regard to commercial support.
© 2014 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.